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Stroke is the most common cause of disability in adults and a leading cause of death worldwide.The drug, Kineret, licensed for treating rheumatoid arthritis, was given as a small injection just under the skin without giving the patients any identifiable adverse reactions.Kineret works by blocking the actions of IL-1 which is released into the body following injury caused by a stroke.According to a study led by the University of Manchester, an anti-inflammatory drug given to patients in the early stages of a stroke has been shown by researchers to reduce harmful inflammation. However, if further trials are successful, we hope it could vastly improve outcomes and quality of life for people who have had a stroke.""We have shown that Kineret injections, started within six hours of stroke onset significantly reduces levels of inflammation in patients.A stroke occurs when poor blood flow to the brain results in cell death.The protein Interleukin-1 (IL-1) is part of the body&Screw barrel of injection moulding machine39;s defences and naturally produced to combat a range of illnesses.

The findings from this study are published in the journal Stroke.."The research has not yet proven that this drug can reduce patient disability after stroke. There are two main types of stroke: ischemic, caused by lack of blood flow, and haemorrhagic, caused by bleeding in the brain. It is funded by the National Institute for Health Research.The team of researchers cannot say for sure at this stage how the reduction in inflammation will impact on clinical outcomes.He said, "Though Strokes affect different people in different ways, for many people they have a devastating effect on their long-term health and wellbeing.To definitively test if Kineret improves patient outcomes in subarachnoid haemorrhage, a national trial of Kineret in 1000 patients, funded by the Medical Research Council and National Institute for Health Research, will start in 2018.Washington: Turns out, this drug reduces inflammation in stroke patients."The same research team has shown that Kineret reduces inflammation and is safe in patients with bleeding around the brain, a condition known as subarachnoid haemorrhage.And another trial in 80 patients with stroke caused bleeding in the brain, known as intracerebral haemorrhage, will also # start in 2018.

This means that it can be used in different settings, for example, it could potentially be given in ambulances on the way to hospital.The Manchester study - a double blind trial where Kineret was tested against placebo - looked at ischemic strokes only."Hilary Reynolds, Executive Director of Strategy & Research at the Stroke Association said, "This study builds on evidence that IL-1Ra (Kineret) helps to reduce inflammation and brain damage in a wide range of stroke patients soon after a stroke. The drug can be given quickly, via injection or via a drip.That trial will test if markers of inflammation are reduced by Kineret and test safety in intracerebral haemorrhage. The brain loses around 2 million brain cells every minute during a stroke, so this could provide a major step forward in fast and effective treatment of stroke.The study follows earlier research that shows the drug given as an intravenous therapy reduces inflammation in stroke and sub arachnoid haemorrhage patients.However, scientists at the University of Manchester have previously shown IL-1 increases inflammation and brain injury following a stroke. The first dose was given within 6 hours after the onset of the stroke symptoms."Excessive inflammation after a stroke is known to be harmful and predicts a worse outcome in patients.Professor Craig Smith from The University of Manchester is also a stroke physician at Salford Royal.The 80 Participants in the study - carried out at Salford's Greater Manchester Stroke Centre at Salford Royal- were given 6 doses of the drug or placebo over three days.It is one of biologic agents transforming treatment in a range of illnesses.Inflammatory markers were measured in the blood before treatment began and during study treatment